Latest Publications

2024

• Identification of Riluzole derivatives as novel calmodulin inhibitors with neuroprotective activity by a joint synthesis, biosensor, and computational guided strategy.
  Maider Baltasar-Marchueta, Leire Llona, M Sara, Iratxe Barbolla, Markel Garcia Ibarluzea, Rafael Ramis, Ane Miren Salomon, Brenda Fundora, Ariane Araujo, Arantza Muguruza-Montero, Eider Nuñez, Scarlett Pérez-Olea, Christian Villanueva, Aritz Leonardo, Sonia Arrasate, Nuria Sotomayor, Alvaro Villarroel, Aitor Bergara, Esther Lete, Humberto González-Díaz.
  Biomedicine & Pharmacotherapy 174, 116602

2023

• Molecular dynamics simulations of the calmodulin-induced α-helix in the SK2 calcium-gated potassium ion channel
  Rafael Ramis, Óscar R. Ballesteros, Arantza Muguruza-Montero, Sara M-Alicante, Eider Núñez, Álvaro Villarroel, Aritz Leonardo, Aitor Bergara.
  Journal of Biological Chemistry 299 (2)

2022

• Improved KCNQ2 gene missense variant interpretation with artificial intelligence
  Alba Saez-Matia, Arantza Muguruza-Montero, Sara M-Alicante, Eider Nunez, Rafael Ramis, Oscar R Ballesteros, Markel G Ibarluzea, Carmen Fons, Aritz Leonardo, Aitor Bergara, Alvaro Villarroel.
  bioRxiv preprint

2021

• An epilepsy-causing mutation leads to co-translational misfolding of the Kv7. 2 channel
  Janire Urrutia, Alejandra Aguado, Carolina Gomis-Perez, Arantza Muguruza-Montero, Oscar R Ballesteros, Jiaren Zhang, Eider Nuñez, Covadonga Malo, Hee Jung Chung, Aritz Leonardo, Aitor Bergara, Alvaro Villarroel.
  BMC Biology

• Do calmodulin binding IQ motifs have built‐in capping domains?
  Arantza Muguruza‐Montero, Rafael Ramis, Eider Nuñez, Oscar R. Ballesteros, Markel G. Ibarluzea, Ariane Araujo, Sara M‐Alicante, Janire Urrutia, Aritz Leonardo, Aitor Bergara, Alvaro Villarroel
  Protein Science